Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4236843..4237359 Replicon chromosome
Accession NZ_CP098834
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain GD19PS1

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NFH28_RS20850 Protein ID WP_000220578.1
Coordinates 4236843..4237127 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NFH28_RS20855 Protein ID WP_000212724.1
Coordinates 4237117..4237359 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH28_RS20835 (4232055) 4232055..4233707 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
NFH28_RS20840 (4234116) 4234116..4236254 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NFH28_RS20845 (4236375) 4236375..4236839 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NFH28_RS20850 (4236843) 4236843..4237127 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFH28_RS20855 (4237117) 4237117..4237359 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NFH28_RS20860 (4237437) 4237437..4239350 - 1914 WP_001212137.1 BglG family transcription antiterminator -
NFH28_RS20865 (4239367) 4239367..4240107 - 741 WP_000779263.1 KDGP aldolase family protein -
NFH28_RS20870 (4240104) 4240104..4241222 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NFH28_RS20875 (4241206) 4241206..4242339 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T248161 WP_000220578.1 NZ_CP098834:c4237127-4236843 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT248161 WP_000212724.1 NZ_CP098834:c4237359-4237117 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References