Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4142582..4143158 Replicon chromosome
Accession NZ_CP098834
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain GD19PS1

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NFH28_RS20455 Protein ID WP_001131963.1
Coordinates 4142871..4143158 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag NFH28_RS20450 Protein ID WP_000063142.1
Coordinates 4142582..4142884 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH28_RS20435 (4139092) 4139092..4141242 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
NFH28_RS20440 (4141337) 4141337..4141540 + 204 WP_000460616.1 YbdD/YjiX family protein -
NFH28_RS20445 (4141551) 4141551..4142507 + 957 WP_000187839.1 GTPase -
NFH28_RS20450 (4142582) 4142582..4142884 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
NFH28_RS20455 (4142871) 4142871..4143158 - 288 WP_001131963.1 BrnT family toxin Toxin
NFH28_RS20460 (4143427) 4143427..4144341 - 915 WP_000290512.1 restriction endonuclease -
NFH28_RS20465 (4144539) 4144539..4148048 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T248160 WP_001131963.1 NZ_CP098834:c4143158-4142871 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT248160 WP_000063142.1 NZ_CP098834:c4142884-4142582 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References