248157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3495617..3496237 Replicon chromosome
Accession NZ_CP098834
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain GD19PS1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NFH28_RS17325 Protein ID WP_001280991.1
Coordinates 3496019..3496237 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NFH28_RS17320 Protein ID WP_000344807.1
Coordinates 3495617..3495991 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH28_RS17310 (3490756) 3490756..3491949 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFH28_RS17315 (3491972) 3491972..3495121 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NFH28_RS17320 (3495617) 3495617..3495991 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NFH28_RS17325 (3496019) 3496019..3496237 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NFH28_RS17330 (3496416) 3496416..3496967 + 552 WP_001278792.1 maltose O-acetyltransferase -
NFH28_RS17335 (3497084) 3497084..3497554 + 471 WP_000136181.1 YlaC family protein -
NFH28_RS17340 (3497610) 3497610..3497750 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NFH28_RS17345 (3497756) 3497756..3498016 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NFH28_RS17350 (3498241) 3498241..3499791 + 1551 WP_000213139.1 EAL domain-containing protein -
NFH28_RS17360 (3500022) 3500022..3500411 + 390 WP_000961285.1 MGMT family protein -
NFH28_RS17365 (3500444) 3500444..3501013 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T248157 WP_001280991.1 NZ_CP098834:3496019-3496237 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT248157 WP_000344807.1 NZ_CP098834:3495617-3495991 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References