Detailed information of TA system TA024815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 208772..209373
• Replicon: plasmid pPag3
• Accession: NC_014258
• Organism: Pantoea vagans C9-1

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: PVAG_RS02490
• Protein ID: WP_041456496.1
• Coordinates: 208990..209373 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: D6YQJ8
• Locus tag: PVAG_RS02485
• Protein ID: WP_013196184.1
• Coordinates: 208772..208993 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PVAG_RS02470	205089..206198	+	1110	WP_013196181.1	maltose/maltodextrin ABC transporter ATP-binding protein MalK	-
PVAG_RS02475	206242..207543	+	1302	WP_013196182.1	maltoporin	-
PVAG_RS02480	207642..208577	+	936	WP_013196183.1	maltose operon protein MalM	-
PVAG_RS02485	208772..208993	+	222	WP_013196184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PVAG_RS02490	208990..209373	+	384	WP_041456496.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
PVAG_RS02495	209536..211602	-	2067	WP_013196185.1	4-alpha-glucanotransferase	-
PVAG_RS02500	211611..214013	-	2403	WP_013196186.1	maltodextrin phosphorylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	iroN / pla	1..529676	529676

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (2-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-58)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14256.41 Da
• Isoelectric Point: 4.8782

>T24815 WP_041456496.1 NC_014258:208990-209373 [Pantoea vagans C9-1]
MKWVSAQEVIAFHDRLLAVLPGIKGMPEPQRAEAIIYRVQNQLYYEGVEDIFVLAAIYLIAISRGHIFNDGNKRTAFFVT
MVFLNRNGIAIRDEDNELEELTVSAATGDATTEVIATVLRRLSFLSP

Nucleotide

• Length: 384 bp

>T24815 NC_014258:208990-209373 [Pantoea vagans C9-1]
ATGAAATGGGTTAGTGCTCAGGAGGTGATAGCTTTTCATGATCGTCTGCTGGCTGTTCTGCCAGGTATCAAGGGTATGCC
AGAACCCCAGAGAGCAGAAGCTATCATTTATAGGGTACAGAACCAGCTCTATTATGAAGGTGTGGAAGATATCTTTGTAT
TAGCCGCCATCTACCTCATCGCTATATCCCGGGGACACATTTTTAATGATGGTAATAAGCGAACTGCATTTTTCGTCACG
ATGGTTTTTTTGAATCGTAACGGCATAGCTATACGTGATGAAGATAATGAACTCGAAGAATTAACGGTATCTGCCGCTAC
TGGTGATGCTACGACTGAGGTCATTGCTACTGTATTGCGGCGATTATCGTTTTTGTCTCCGTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8145.02 Da
• Isoelectric Point: 4.7527

>AT24815 WP_013196184.1 NC_014258:208772-208993 [Pantoea vagans C9-1]
MRSYTTTEARQNIAEVMDTATAGEPVEITRRDGSSAVLISRDDFNAWQEAKLDAEFADIMGRHSRTVKALADR

Nucleotide

• Length: 222 bp

>AT24815 NC_014258:208772-208993 [Pantoea vagans C9-1]
ATGCGTAGTTACACCACCACTGAGGCCCGACAAAACATTGCTGAAGTCATGGACACAGCTACGGCCGGTGAGCCTGTAGA
AATAACCCGGCGCGATGGTTCTTCTGCTGTACTTATCAGTCGCGACGATTTTAATGCCTGGCAGGAAGCAAAACTGGATG
CCGAATTTGCCGACATTATGGGGCGACATTCACGTACGGTGAAGGCACTGGCTGACCGATGA

Structures

Antitoxin

• AlphaFold DB: D6YQJ8