Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870729..871389 Replicon chromosome
Accession NZ_CP098834
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain GD19PS1

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NFH28_RS04225 Protein ID WP_000244756.1
Coordinates 870976..871389 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NFH28_RS04220 Protein ID WP_000351186.1
Coordinates 870729..870995 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH28_RS04200 (866657) 866657..868090 - 1434 WP_252321606.1 6-phospho-beta-glucosidase BglA -
NFH28_RS04205 (868249) 868249..868560 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NFH28_RS04210 (868724) 868724..869383 + 660 WP_000250289.1 hemolysin III family protein -
NFH28_RS04215 (869499) 869499..870479 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
NFH28_RS04220 (870729) 870729..870995 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NFH28_RS04225 (870976) 870976..871389 + 414 WP_000244756.1 protein YgfX Toxin
NFH28_RS04230 (871442) 871442..871963 - 522 WP_001055885.1 flavodoxin FldB -
NFH28_RS04235 (872076) 872076..872972 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NFH28_RS04240 (872996) 872996..873709 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFH28_RS04245 (873715) 873715..875448 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T248149 WP_000244756.1 NZ_CP098834:870976-871389 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT248149 WP_000351186.1 NZ_CP098834:870729-870995 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References