Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 142317..143940 | Replicon | plasmid pYUYZMCS14-1 |
| Accession | NZ_CP098832 | ||
| Organism | Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS14 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | H9TH67 |
| Locus tag | NFH10_RS24320 | Protein ID | WP_000088046.1 |
| Coordinates | 142317..143642 (-) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
| Locus tag | NFH10_RS24325 | Protein ID | WP_024136327.1 |
| Coordinates | 143647..143940 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NFH10_RS24280 (NFH10_24280) | 137578..138051 | - | 474 | WP_001389366.1 | trimethoprim-resistant dihydrofolate reductase DfrA17 | - |
| NFH10_RS24285 (NFH10_24285) | 138209..139222 | + | 1014 | WP_000845048.1 | class 1 integron integrase IntI1 | - |
| NFH10_RS24290 (NFH10_24290) | 139425..139775 | + | 351 | WP_000454193.1 | DUF3330 domain-containing protein | - |
| NFH10_RS24295 (NFH10_24295) | 139901..140476 | + | 576 | WP_072740834.1 | recombinase family protein | - |
| NFH10_RS24300 (NFH10_24300) | 140523..141227 | + | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| NFH10_RS24305 (NFH10_24305) | 141280..141525 | - | 246 | Protein_158 | HNH endonuclease | - |
| NFH10_RS24310 (NFH10_24310) | 141538..141948 | - | 411 | WP_000985911.1 | hypothetical protein | - |
| NFH10_RS24315 (NFH10_24315) | 142050..142256 | - | 207 | WP_000134171.1 | hypothetical protein | - |
| NFH10_RS24320 (NFH10_24320) | 142317..143642 | - | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| NFH10_RS24325 (NFH10_24325) | 143647..143940 | - | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| NFH10_RS24330 (NFH10_24330) | 144545..144937 | - | 393 | WP_000341066.1 | hypothetical protein | - |
| NFH10_RS24335 (NFH10_24335) | 145310..145651 | + | 342 | WP_001151575.1 | hypothetical protein | - |
| NFH10_RS24340 (NFH10_24340) | 145743..145934 | + | 192 | WP_000398480.1 | hypothetical protein | - |
| NFH10_RS24345 (NFH10_24345) | 145984..146265 | + | 282 | WP_000077926.1 | hypothetical protein | - |
| NFH10_RS24810 | 146606..146737 | - | 132 | WP_000374059.1 | hypothetical protein | - |
| NFH10_RS24350 (NFH10_24350) | 146828..148069 | - | 1242 | WP_001053338.1 | VWA domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | mcr-1.1 / oqxB / lnu(F) / ant(3'')-Ia / fosA3 / blaTEM-1B / floR / sul2 / aph(4)-Ia / aac(3)-IVa / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / tet(A) / rmtB / mph(A) / aph(6)-Id / aph(3'')-Ib / aadA5 / dfrA17 | - | 1..229976 | 229976 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T248145 WP_000088046.1 NZ_CP098832:c143642-142317 [Salmonella enterica subsp. enterica serovar Indiana]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10946.35 Da Isoelectric Point: 10.0925
>AT248145 WP_024136327.1 NZ_CP098832:c143940-143647 [Salmonella enterica subsp. enterica serovar Indiana]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3T0VBU1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Z6V2D1 |