Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4190338..4190854 Replicon chromosome
Accession NZ_CP098831
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS14

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag NFH10_RS20625 Protein ID WP_000220577.1
Coordinates 4190338..4190622 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NFH10_RS20630 Protein ID WP_000212724.1
Coordinates 4190612..4190854 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH10_RS20610 (4185454) 4185454..4187106 + 1653 WP_000155050.1 alpha,alpha-phosphotrehalase -
NFH10_RS20615 (4187515) 4187515..4189653 + 2139 WP_023226981.1 anaerobic ribonucleoside-triphosphate reductase -
NFH10_RS20620 (4189870) 4189870..4190334 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NFH10_RS20625 (4190338) 4190338..4190622 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFH10_RS20630 (4190612) 4190612..4190854 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NFH10_RS20635 (4190932) 4190932..4192845 - 1914 WP_023226980.1 BglG family transcription antiterminator -
NFH10_RS20640 (4192862) 4192862..4193602 - 741 WP_000779254.1 KDGP aldolase family protein -
NFH10_RS20645 (4193599) 4193599..4194717 - 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NFH10_RS20650 (4194701) 4194701..4195834 - 1134 WP_023226979.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T248141 WP_000220577.1 NZ_CP098831:c4190622-4190338 [Salmonella enterica subsp. enterica serovar Indiana]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT248141 WP_000212724.1 NZ_CP098831:c4190854-4190612 [Salmonella enterica subsp. enterica serovar Indiana]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References