Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 16447..17357 Replicon plasmid pPag3
Accession NC_014258
Organism Pantoea vagans C9-1

Toxin (Protein)


Gene name - Uniprot ID D6YQ02
Locus tag PVAG_RS01580 Protein ID WP_013195989.1
Coordinates 16447..16917 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID D6YQ03
Locus tag PVAG_RS01585 Protein ID WP_013195990.1
Coordinates 16914..17357 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVAG_RS01570 12524..15253 + 2730 WP_013195987.1 cation-transporting P-type ATPase -
PVAG_RS01575 15242..16273 - 1032 WP_013195988.1 AI-2E family transporter -
PVAG_RS01580 16447..16917 - 471 WP_013195989.1 RES family NAD+ phosphorylase Toxin
PVAG_RS01585 16914..17357 - 444 WP_013195990.1 DUF2384 domain-containing protein Antitoxin
PVAG_RS01590 17506..18120 + 615 WP_041456446.1 TetR/AcrR family transcriptional regulator -
PVAG_RS01595 18172..19038 + 867 WP_013195992.1 alpha/beta hydrolase -
PVAG_RS01600 19313..20500 + 1188 WP_013195993.1 amidohydrolase -
PVAG_RS01605 20522..21370 + 849 WP_013195994.1 transporter substrate-binding domain-containing protein -
PVAG_RS01610 21377..22102 + 726 WP_013195995.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN / pla 1..529676 529676


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(32-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17395.81 Da        Isoelectric Point: 4.7761

>T24814 WP_013195989.1 NC_014258:c16917-16447 [Pantoea vagans C9-1]
MILYRLTKTKYLSTAWTGFGAKEAGGRWNSIGISMVYVSETASLTLLETLVHLHSAHILDAFTLLRIDVPDALIQTVDIS
ELPANWADEDVPAELADYGDAWCSACDAVALLVPSALSPTEHNYLLNPEHPEFSRIVQQAEAIPFRFDRRLKPDRK

Download         Length: 471 bp

>T24814 NC_014258:c16917-16447 [Pantoea vagans C9-1]
TTGATCCTCTACAGGCTGACTAAGACAAAGTATCTTTCGACCGCCTGGACGGGATTCGGCGCAAAAGAGGCGGGCGGTCG
CTGGAACAGCATCGGCATCTCAATGGTTTATGTCTCAGAAACCGCCTCACTGACGTTGCTGGAAACACTGGTCCATCTGC
ACTCAGCACACATCCTCGACGCTTTCACGCTACTGCGCATCGATGTTCCCGATGCGCTGATACAAACCGTCGATATCAGT
GAATTGCCTGCAAACTGGGCCGATGAAGACGTGCCGGCGGAACTGGCTGACTATGGCGACGCCTGGTGCTCTGCCTGCGA
TGCGGTTGCGTTGCTAGTTCCCAGTGCTCTATCTCCTACAGAACACAACTATCTGTTAAATCCTGAACACCCGGAGTTTT
CCCGGATCGTTCAACAGGCTGAGGCCATTCCGTTCCGGTTTGACCGTCGGCTGAAACCGGACCGTAAATAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16453.83 Da        Isoelectric Point: 9.5911

>AT24814 WP_013195990.1 NC_014258:c17357-16914 [Pantoea vagans C9-1]
MKTFSFSAAKTRPPRLWQAAGLHSTDGVALLGQINDGLDGNVAHLIIDWAKITQNDLRRMSGIPSTTFSRGVKAKFSAEQ
SERLVRIIRVIDRAVELFEGDKDEAQKWLNEPNRALSWKMPAELMASETGAYEVLKLITRLEHGVYS

Download         Length: 444 bp

>AT24814 NC_014258:c17357-16914 [Pantoea vagans C9-1]
ATGAAAACATTCAGTTTTTCTGCAGCTAAGACCAGACCGCCACGTTTATGGCAGGCTGCGGGCCTGCACAGTACGGATGG
TGTCGCTCTGCTGGGCCAGATCAACGATGGCCTCGATGGCAACGTGGCTCACCTCATCATCGACTGGGCGAAGATTACCC
AAAATGACCTGCGCAGAATGTCCGGTATTCCCTCCACGACGTTCAGCCGTGGCGTGAAAGCGAAATTCAGCGCTGAACAA
AGCGAACGACTGGTGCGGATTATCCGCGTTATTGATCGGGCGGTTGAATTGTTTGAAGGCGATAAGGATGAAGCGCAAAA
ATGGCTGAATGAGCCTAACCGGGCGTTGAGCTGGAAAATGCCAGCAGAACTTATGGCATCGGAAACCGGCGCTTATGAGG
TCCTGAAGCTCATCACGCGTCTGGAGCATGGAGTTTATTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D6YQ02

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z1Y7E4

References