Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3369136..3369756 Replicon chromosome
Accession NZ_CP098831
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS14

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NFH10_RS16455 Protein ID WP_001280991.1
Coordinates 3369538..3369756 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NFH10_RS16450 Protein ID WP_000344807.1
Coordinates 3369136..3369510 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH10_RS16440 (3364275) 3364275..3365468 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFH10_RS16445 (3365491) 3365491..3368640 + 3150 WP_252321704.1 efflux RND transporter permease AcrB -
NFH10_RS16450 (3369136) 3369136..3369510 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NFH10_RS16455 (3369538) 3369538..3369756 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NFH10_RS16460 (3369935) 3369935..3370486 + 552 WP_001278793.1 maltose O-acetyltransferase -
NFH10_RS16465 (3370604) 3370604..3371074 + 471 WP_000136181.1 YlaC family protein -
NFH10_RS16470 (3371130) 3371130..3371270 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NFH10_RS16475 (3371276) 3371276..3371536 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NFH10_RS16480 (3371761) 3371761..3373311 + 1551 WP_023210786.1 EAL domain-containing protein -
NFH10_RS16490 (3373542) 3373542..3373931 + 390 WP_000961285.1 MGMT family protein -
NFH10_RS16495 (3373964) 3373964..3374533 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T248138 WP_001280991.1 NZ_CP098831:3369538-3369756 [Salmonella enterica subsp. enterica serovar Indiana]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT248138 WP_000344807.1 NZ_CP098831:3369136-3369510 [Salmonella enterica subsp. enterica serovar Indiana]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References