Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2393137..2393659 Replicon chromosome
Accession NZ_CP098831
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS14

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NFH10_RS11590 Protein ID WP_000221343.1
Coordinates 2393375..2393659 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NFH10_RS11585 Protein ID WP_000885424.1
Coordinates 2393137..2393385 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH10_RS11565 (2388779) 2388779..2390245 + 1467 WP_023893409.1 hypothetical protein -
NFH10_RS24790 (2390276) 2390276..2390398 - 123 WP_254891910.1 hypothetical protein -
NFH10_RS11570 (2390862) 2390862..2391149 + 288 WP_071787797.1 helix-turn-helix domain-containing protein -
NFH10_RS11575 (2391221) 2391221..2392129 - 909 WP_077910000.1 hypothetical protein -
NFH10_RS11580 (2392280) 2392280..2392612 - 333 WP_023227504.1 DUF1493 family protein -
NFH10_RS11585 (2393137) 2393137..2393385 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NFH10_RS11590 (2393375) 2393375..2393659 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFH10_RS11595 (2393707) 2393707..2393907 + 201 Protein_2271 Rid family hydrolase -
NFH10_RS11600 (2393959) 2393959..2395038 - 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NFH10_RS11605 (2395231) 2395231..2395719 - 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
NFH10_RS11610 (2395764) 2395764..2397272 + 1509 WP_023227500.1 FAD-dependent oxidoreductase -
NFH10_RS11615 (2397262) 2397262..2398503 + 1242 WP_023227499.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2390294..2400129 9835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T248137 WP_000221343.1 NZ_CP098831:2393375-2393659 [Salmonella enterica subsp. enterica serovar Indiana]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT248137 WP_000885424.1 NZ_CP098831:2393137-2393385 [Salmonella enterica subsp. enterica serovar Indiana]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References