Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 823309..823934 Replicon chromosome
Accession NZ_CP098831
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS14

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NFH10_RS03975 Protein ID WP_000911337.1
Coordinates 823536..823934 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag NFH10_RS03970 Protein ID WP_000557545.1
Coordinates 823309..823536 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH10_RS03940 (818354) 818354..819871 + 1518 WP_000003339.1 lysine--tRNA ligase -
NFH10_RS03945 (819947) 819947..820492 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NFH10_RS03950 (820757) 820757..821515 + 759 WP_000244318.1 amidase activator ActS -
NFH10_RS03960 (821800) 821800..822606 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NFH10_RS03965 (822881) 822881..823141 - 261 WP_023227725.1 hypothetical protein -
NFH10_RS03970 (823309) 823309..823536 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
NFH10_RS03975 (823536) 823536..823934 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
NFH10_RS03980 (824738) 824738..825274 + 537 WP_023227726.1 STM3031 family outer membrane protein -
NFH10_RS03985 (825321) 825321..825953 + 633 WP_023227727.1 YfdX family protein -
NFH10_RS03990 (826672) 826672..827259 + 588 WP_023227728.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 821800..833127 11327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T248131 WP_000911337.1 NZ_CP098831:823536-823934 [Salmonella enterica subsp. enterica serovar Indiana]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT248131 WP_000557545.1 NZ_CP098831:823309-823536 [Salmonella enterica subsp. enterica serovar Indiana]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References