Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812422..813082 Replicon chromosome
Accession NZ_CP098831
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS14

Toxin (Protein)


Gene name cptA Uniprot ID A0A3V4SJP5
Locus tag NFH10_RS03910 Protein ID WP_000244755.1
Coordinates 812669..813082 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NFH10_RS03905 Protein ID WP_000351186.1
Coordinates 812422..812688 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFH10_RS03885 (808729) 808729..809040 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NFH10_RS03890 (809204) 809204..809863 + 660 WP_000250289.1 hemolysin III family protein -
NFH10_RS03895 (810121) 810121..811109 + 989 Protein_764 IS110 family transposase -
NFH10_RS03900 (811192) 811192..812172 - 981 WP_017441090.1 tRNA-modifying protein YgfZ -
NFH10_RS03905 (812422) 812422..812688 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NFH10_RS03910 (812669) 812669..813082 + 414 WP_000244755.1 protein YgfX Toxin
NFH10_RS03915 (813135) 813135..813656 - 522 WP_001055885.1 flavodoxin FldB -
NFH10_RS03920 (813769) 813769..814665 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NFH10_RS03925 (814689) 814689..815402 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFH10_RS03930 (815408) 815408..817141 + 1734 WP_023227724.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16164.10 Da        Isoelectric Point: 10.2118

>T248130 WP_000244755.1 NZ_CP098831:812669-813082 [Salmonella enterica subsp. enterica serovar Indiana]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLHPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT248130 WP_000351186.1 NZ_CP098831:812422-812688 [Salmonella enterica subsp. enterica serovar Indiana]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SJP5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References