Detailed information of TA system TA024813

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 631976..632654
• Replicon: chromosome
• Accession: NC_014256
• Organism: Helicobacter pylori B8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPB8_RS03130
• Protein ID: WP_080006198.1
• Coordinates: 632331..632654 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D7FDF9
• Locus tag: HPB8_RS03125
• Protein ID: WP_001134161.1
• Coordinates: 631976..632350 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPB8_RS08330	627480..627877	+	398	Protein_583	hypothetical protein	-
HPB8_RS03115	628783..630990	+	2208	WP_000716232.1	Hop family adhesin BabA	-
HPB8_RS03125	631976..632350	+	375	WP_001134161.1	hypothetical protein	Antitoxin
HPB8_RS03130	632331..632654	+	324	WP_080006198.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPB8_RS03135	632699..633223	-	525	WP_001135637.1	acyl-CoA thioesterase	-
HPB8_RS03140	633363..634211	+	849	WP_000504111.1	SDR family oxidoreductase	-
HPB8_RS03145	634204..635184	+	981	WP_000921449.1	iron ABC transporter permease	-
HPB8_RS03150	635184..635951	+	768	WP_000242349.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12475.74 Da
• Isoelectric Point: 9.5268

>T24813 WP_080006198.1 NC_014256:632331-632654 [Helicobacter pylori B8]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILRKKEPLDPQFQDHALKGKWKPYRECHIKPDILLVYLVKDDELILLRLG
SHSELFCKSPTQFITLKPTAQPTTPLF

Nucleotide

• Length: 324 bp

>T24813 NC_014256:632331-632654 [Helicobacter pylori B8]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAAGAAAGAAAGAACCGCTAGATCCACAATTTCAAGATCATGCCCTAAAAGGCAAGTGGAAGCCTT
ATAGAGAATGCCACATTAAGCCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGGTTAGGC
AGTCATAGCGAGCTGTTTTGTAAATCACCCACACAATTTATAACGCTTAAACCAACCGCTCAACCAACTACCCCCCTTTT
TTAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14713.64 Da
• Isoelectric Point: 7.8113

>AT24813 WP_001134161.1 NC_014256:631976-632350 [Helicobacter pylori B8]
MPNTTNKDYTQYSEKQLFNLIHQLEQKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCLG
RKIPNIQTQQAMRDVYNKETDLIVEDFSSYSDERKKALGVETQS

Nucleotide

• Length: 375 bp

>AT24813 NC_014256:631976-632350 [Helicobacter pylori B8]
ATGCCAAACACCACCAACAAAGATTACACCCAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCAAAA
AATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACTTTA
AGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTGGGG
CGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGTGTATAACAAAGAAACAGATTTGATTGTTGAGGATTT
TTCTAGTTACAGCGATGAGAGAAAAAAGGCTTTGGGTGTTGAAACTCAATCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2L2I1T1