Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4303023..4303539 Replicon chromosome
Accession NZ_CP098829
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS6

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag NFG92_RS21160 Protein ID WP_000220577.1
Coordinates 4303023..4303307 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NFG92_RS21165 Protein ID WP_000212724.1
Coordinates 4303297..4303539 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFG92_RS21145 (4298139) 4298139..4299791 + 1653 WP_000155050.1 alpha,alpha-phosphotrehalase -
NFG92_RS21150 (4300200) 4300200..4302338 + 2139 WP_023226981.1 anaerobic ribonucleoside-triphosphate reductase -
NFG92_RS21155 (4302555) 4302555..4303019 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NFG92_RS21160 (4303023) 4303023..4303307 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFG92_RS21165 (4303297) 4303297..4303539 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NFG92_RS21170 (4303617) 4303617..4305530 - 1914 WP_023226980.1 BglG family transcription antiterminator -
NFG92_RS21175 (4305547) 4305547..4306287 - 741 WP_000779254.1 KDGP aldolase family protein -
NFG92_RS21180 (4306284) 4306284..4307402 - 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NFG92_RS21185 (4307386) 4307386..4308519 - 1134 WP_023226979.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T248127 WP_000220577.1 NZ_CP098829:c4303307-4303023 [Salmonella enterica subsp. enterica serovar Indiana]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT248127 WP_000212724.1 NZ_CP098829:c4303539-4303297 [Salmonella enterica subsp. enterica serovar Indiana]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References