Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3524772..3525392 Replicon chromosome
Accession NZ_CP098829
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS6

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NFG92_RS17325 Protein ID WP_001280991.1
Coordinates 3525174..3525392 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NFG92_RS17320 Protein ID WP_000344807.1
Coordinates 3524772..3525146 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFG92_RS17310 (3519911) 3519911..3521104 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFG92_RS17315 (3521127) 3521127..3524276 + 3150 WP_051129102.1 efflux RND transporter permease AcrB -
NFG92_RS17320 (3524772) 3524772..3525146 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NFG92_RS17325 (3525174) 3525174..3525392 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NFG92_RS17330 (3525571) 3525571..3526122 + 552 WP_001278793.1 maltose O-acetyltransferase -
NFG92_RS17335 (3526240) 3526240..3526710 + 471 WP_000136181.1 YlaC family protein -
NFG92_RS17340 (3526766) 3526766..3526906 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NFG92_RS17345 (3526912) 3526912..3527172 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NFG92_RS17350 (3527397) 3527397..3528947 + 1551 WP_023210786.1 EAL domain-containing protein -
NFG92_RS17360 (3529178) 3529178..3529567 + 390 WP_000961285.1 MGMT family protein -
NFG92_RS17365 (3529600) 3529600..3530169 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T248124 WP_001280991.1 NZ_CP098829:3525174-3525392 [Salmonella enterica subsp. enterica serovar Indiana]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT248124 WP_000344807.1 NZ_CP098829:3524772-3525146 [Salmonella enterica subsp. enterica serovar Indiana]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References