248123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2546195..2546717 Replicon chromosome
Accession NZ_CP098829
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS6

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NFG92_RS12460 Protein ID WP_000221343.1
Coordinates 2546433..2546717 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NFG92_RS12455 Protein ID WP_000885424.1
Coordinates 2546195..2546443 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFG92_RS12435 (2541837) 2541837..2543303 + 1467 WP_023893409.1 hypothetical protein -
NFG92_RS24480 (2543334) 2543334..2543456 - 123 WP_254891910.1 hypothetical protein -
NFG92_RS12440 (2543920) 2543920..2544207 + 288 WP_071787797.1 helix-turn-helix domain-containing protein -
NFG92_RS12445 (2544279) 2544279..2545187 - 909 WP_077910000.1 hypothetical protein -
NFG92_RS12450 (2545338) 2545338..2545670 - 333 WP_023227504.1 DUF1493 family protein -
NFG92_RS12455 (2546195) 2546195..2546443 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NFG92_RS12460 (2546433) 2546433..2546717 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NFG92_RS12465 (2546765) 2546765..2546965 + 201 Protein_2445 Rid family hydrolase -
NFG92_RS12470 (2547017) 2547017..2548096 - 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NFG92_RS12475 (2548289) 2548289..2548777 - 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
NFG92_RS12480 (2548822) 2548822..2550330 + 1509 WP_023227500.1 FAD-dependent oxidoreductase -
NFG92_RS12485 (2550320) 2550320..2551561 + 1242 WP_023227499.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2543352..2553187 9835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T248123 WP_000221343.1 NZ_CP098829:2546433-2546717 [Salmonella enterica subsp. enterica serovar Indiana]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT248123 WP_000885424.1 NZ_CP098829:2546195-2546443 [Salmonella enterica subsp. enterica serovar Indiana]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References