248118

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1561109..1562732 Replicon chromosome
Accession NZ_CP098829
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS6

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag NFG92_RS07505 Protein ID WP_000088046.1
Coordinates 1561407..1562732 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag NFG92_RS07500 Protein ID WP_024136327.1
Coordinates 1561109..1561402 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFG92_RS07475 (1556981) 1556981..1558222 + 1242 WP_001053338.1 VWA domain-containing protein -
NFG92_RS24465 (1558313) 1558313..1558444 + 132 WP_000374059.1 hypothetical protein -
NFG92_RS07480 (1558785) 1558785..1559066 - 282 WP_000077926.1 hypothetical protein -
NFG92_RS07485 (1559116) 1559116..1559307 - 192 WP_000398480.1 hypothetical protein -
NFG92_RS07490 (1559399) 1559399..1559740 - 342 WP_001151575.1 hypothetical protein -
NFG92_RS07495 (1560113) 1560113..1560505 + 393 WP_000341066.1 hypothetical protein -
NFG92_RS07500 (1561109) 1561109..1561402 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
NFG92_RS07505 (1561407) 1561407..1562732 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
NFG92_RS07510 (1562793) 1562793..1562999 + 207 WP_000134171.1 hypothetical protein -
NFG92_RS07515 (1563101) 1563101..1563511 + 411 WP_000985911.1 hypothetical protein -
NFG92_RS07520 (1563524) 1563524..1564339 + 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
NFG92_RS07525 (1564593) 1564593..1565018 + 426 WP_001043843.1 hypothetical protein -
NFG92_RS07530 (1565567) 1565567..1565875 + 309 WP_001224687.1 hypothetical protein -
NFG92_RS07535 (1565891) 1565891..1566748 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island cmlA1 / ant(3'')-Ia / sul3 / aph(3')-Ia / mph(A) / floR / sul2 / aph(4)-Ia / aac(3)-IVa - 1558785..1602826 44041


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T248118 WP_000088046.1 NZ_CP098829:1561407-1562732 [Salmonella enterica subsp. enterica serovar Indiana]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT248118 WP_024136327.1 NZ_CP098829:1561109-1561402 [Salmonella enterica subsp. enterica serovar Indiana]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References