Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 896170..896795 Replicon chromosome
Accession NZ_CP098829
Organism Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NFG92_RS04420 Protein ID WP_000911337.1
Coordinates 896397..896795 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag NFG92_RS04415 Protein ID WP_000557545.1
Coordinates 896170..896397 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFG92_RS04385 (891215) 891215..892732 + 1518 WP_000003339.1 lysine--tRNA ligase -
NFG92_RS04390 (892808) 892808..893353 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NFG92_RS04395 (893618) 893618..894376 + 759 WP_000244318.1 amidase activator ActS -
NFG92_RS04405 (894661) 894661..895467 - 807 WP_010989071.1 DUF1460 domain-containing protein -
NFG92_RS04410 (895742) 895742..896002 - 261 WP_023227725.1 hypothetical protein -
NFG92_RS04415 (896170) 896170..896397 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
NFG92_RS04420 (896397) 896397..896795 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
NFG92_RS04425 (897599) 897599..898135 + 537 WP_023227726.1 STM3031 family outer membrane protein -
NFG92_RS04430 (898182) 898182..898814 + 633 WP_023227727.1 YfdX family protein -
NFG92_RS04435 (899533) 899533..900120 + 588 WP_023227728.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 894661..905988 11327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T248116 WP_000911337.1 NZ_CP098829:896397-896795 [Salmonella enterica subsp. enterica serovar Indiana]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT248116 WP_000557545.1 NZ_CP098829:896170-896397 [Salmonella enterica subsp. enterica serovar Indiana]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References