Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1257354..1258024 Replicon plasmid pB
Accession NZ_CP098809
Organism Ensifer adhaerens strain M8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NE863_RS32885 Protein ID WP_252160988.1
Coordinates 1257354..1257773 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NE863_RS32890 Protein ID WP_034798588.1
Coordinates 1257770..1258024 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE863_RS32860 (NE863_32860) 1252675..1253547 - 873 WP_252160984.1 DMT family transporter -
NE863_RS32865 (NE863_32865) 1253555..1254526 - 972 WP_060644205.1 amino acid ABC transporter permease -
NE863_RS32870 (NE863_32870) 1254556..1255836 - 1281 WP_252160985.1 FAD-binding oxidoreductase -
NE863_RS32875 (NE863_32875) 1255896..1256723 - 828 WP_252160986.1 transporter substrate-binding domain-containing protein -
NE863_RS32880 (NE863_32880) 1257028..1257282 - 255 WP_252160987.1 hypothetical protein -
NE863_RS32885 (NE863_32885) 1257354..1257773 - 420 WP_252160988.1 type II toxin-antitoxin system VapC family toxin Toxin
NE863_RS32890 (NE863_32890) 1257770..1258024 - 255 WP_034798588.1 plasmid stabilization protein Antitoxin
NE863_RS32895 (NE863_32895) 1258200..1258379 - 180 Protein_1135 DNA ligase -
NE863_RS32900 (NE863_32900) 1258538..1258891 - 354 WP_034798587.1 response regulator -
NE863_RS32905 (NE863_32905) 1258915..1259907 - 993 WP_127890243.1 PAS domain-containing sensor histidine kinase -
NE863_RS32910 (NE863_32910) 1260833..1261084 + 252 WP_063979521.1 hypothetical protein -
NE863_RS32915 (NE863_32915) 1261072..1261473 - 402 Protein_1139 hypothetical protein -
NE863_RS32920 (NE863_32920) 1261927..1262154 - 228 WP_082936641.1 helix-turn-helix domain-containing protein -
NE863_RS32925 (NE863_32925) 1262301..1262984 + 684 WP_252160989.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..1701077 1701077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14866.98 Da        Isoelectric Point: 4.6556

>T248113 WP_252160988.1 NZ_CP098809:c1257773-1257354 [Ensifer adhaerens]
MIVLDTNVVSEAMKPAPDLAVRNWLNDQVAETLFLSSVTLAELLFGIAALPEGRRKKALADTLDGLLELFDDRVLSFDPA
AARHYADLTATARAVGKGFQTPDGYIAAIAASKGFTIATRDTSPFEAAGVPVVNPWNHL

Download         Length: 420 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9553.82 Da        Isoelectric Point: 5.1786

>AT248113 WP_034798588.1 NZ_CP098809:c1258024-1257770 [Ensifer adhaerens]
MAILTVRNVPDEVHRALRVRAANHGRSTEAEVREILERAVKPEQRIRIGDALAELSGRLGLTNDDFEVFDQMQDKAPAEP
MRFE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References