Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 758603..759144 Replicon plasmid pB
Accession NZ_CP098809
Organism Ensifer adhaerens strain M8

Toxin (Protein)


Gene name parE Uniprot ID A0A1H0CJK8
Locus tag NE863_RS30700 Protein ID WP_034798189.1
Coordinates 758603..758896 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1H0CJP6
Locus tag NE863_RS30705 Protein ID WP_034798187.1
Coordinates 758896..759144 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE863_RS30675 (NE863_30675) 754602..755075 - 474 WP_090302489.1 SRPBCC family protein -
NE863_RS30680 (NE863_30680) 755068..755583 - 516 WP_252161401.1 SgcJ/EcaC family oxidoreductase -
NE863_RS30685 (NE863_30685) 755583..755831 - 249 WP_060529873.1 hypothetical protein -
NE863_RS30690 (NE863_30690) 755927..756865 + 939 WP_252161402.1 LysR family transcriptional regulator -
NE863_RS30695 (NE863_30695) 757092..758531 + 1440 WP_252161403.1 NAD-dependent succinate-semialdehyde dehydrogenase -
NE863_RS30700 (NE863_30700) 758603..758896 - 294 WP_034798189.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NE863_RS30705 (NE863_30705) 758896..759144 - 249 WP_034798187.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
NE863_RS30710 (NE863_30710) 759415..760872 + 1458 WP_250806794.1 MDR family MFS transporter -
NE863_RS30715 (NE863_30715) 760923..763616 - 2694 WP_252161404.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..1701077 1701077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10969.62 Da        Isoelectric Point: 6.9895

>T248112 WP_034798189.1 NZ_CP098809:c758896-758603 [Ensifer adhaerens]
MAFRLSVAAEEDIIAIAADGVRLFGSAQARRYHDELFAVFALIAANPRMARERTELSPPMRIHPFKAHLVVYRVEADGDI
LVVRVRHGHEDWISNAF

Download         Length: 294 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9247.39 Da        Isoelectric Point: 8.5610

>AT248112 WP_034798187.1 NZ_CP098809:c759144-758896 [Ensifer adhaerens]
MATMNVSLPDPMKDWVEAQTRTGRYANASDYVRDLIRRDQERNDKVAVMQRFVDDGLKSGVGSRSKDELFSAALTRAEVP
RG

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H0CJK8

Antitoxin

Source ID Structure
AlphaFold DB A0A1H0CJP6

References