Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1119012..1119712 Replicon plasmid pA
Accession NZ_CP098808
Organism Ensifer adhaerens strain M8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NE863_RS24385 Protein ID WP_252160673.1
Coordinates 1119275..1119712 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1H0BN26
Locus tag NE863_RS24380 Protein ID WP_034800189.1
Coordinates 1119012..1119278 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE863_RS24360 (NE863_24360) 1115351..1116400 + 1050 WP_060529687.1 ABC transporter permease -
NE863_RS24365 (NE863_24365) 1116402..1117343 + 942 WP_034800188.1 ABC transporter permease -
NE863_RS24370 (NE863_24370) 1117340..1118632 + 1293 WP_252160672.1 amidohydrolase family protein -
NE863_RS24375 (NE863_24375) 1118679..1118833 - 155 Protein_993 transcriptional regulator -
NE863_RS24380 (NE863_24380) 1119012..1119278 + 267 WP_034800189.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NE863_RS24385 (NE863_24385) 1119275..1119712 + 438 WP_252160673.1 type II toxin-antitoxin system VapC family toxin Toxin
NE863_RS24390 (NE863_24390) 1119989..1120237 + 249 WP_060643745.1 hypothetical protein -
NE863_RS24395 (NE863_24395) 1120454..1121494 + 1041 WP_060643746.1 ABC transporter substrate-binding protein -
NE863_RS24400 (NE863_24400) 1121575..1122384 + 810 WP_246802053.1 ABC transporter permease -
NE863_RS24405 (NE863_24405) 1122400..1123203 + 804 WP_113136167.1 ABC transporter permease -
NE863_RS24410 (NE863_24410) 1123200..1124288 + 1089 WP_089045655.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - katA 1..1753114 1753114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

SpoVT-AbrB domain

(17-54)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15364.78 Da        Isoelectric Point: 6.9280

>T248110 WP_252160673.1 NZ_CP098808:1119275-1119712 [Ensifer adhaerens]
VSNLFMLDTNIVFELARNPRGQVAERIAAVGSEAICVSIITAAELRYGCAKKGSPKLLAQIEALLESILVLALDVPADAK
YGNIRTELEAAGKPIGPNDLLIAAHACAAGAVLVTANAREFTRIPNLRVENWLDATSKQLRGASN

Download         Length: 438 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.58 Da        Isoelectric Point: 4.8781

>AT248110 WP_034800189.1 NZ_CP098808:1119012-1119278 [Ensifer adhaerens]
MPQIRHNEPPAREAKLFRNNKSQAVRIPADFELPGDRVMIHRDGDRLIIEPLRRKNLLEVLAGLDPLGPEDQFPDIDETL
LPAKEIDL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1H0BN26

References