Detailed information of TA system TA024811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1174430..1174928
• Replicon: chromosome
• Accession: NC_014251
• Organism: Streptococcus pneumoniae TCH8431/19A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HMPREF0837_RS06130
• Protein ID: WP_001812387.1
• Coordinates: 1174674..1174928 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: HMPREF0837_RS06125
• Protein ID: WP_000208080.1
• Coordinates: 1174430..1174672 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0837_RS06105	1170252..1171427	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
HMPREF0837_RS06110	1171482..1172186	+	705	WP_000722076.1	response regulator transcription factor	-
HMPREF0837_RS06115	1172179..1173528	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
HMPREF0837_RS06120	1173530..1174339	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
HMPREF0837_RS06125	1174430..1174672	+	243	WP_000208080.1	hypothetical protein	Antitoxin
HMPREF0837_RS06130	1174674..1174928	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HMPREF0837_RS06135	1174975..1175748	+	774	WP_000731129.1	ion transporter	-
HMPREF0837_RS06140	1176064..1177410	-	1347	WP_001814919.1	IS1380-like element ISSpn5 family transposase	-
HMPREF0837_RS06145	1177719..1178705	-	987	WP_000204727.1	L-lactate dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1176064..1177410	1346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T24811 WP_001812387.1 NC_014251:1174674-1174928 [Streptococcus pneumoniae TCH8431/19A]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T24811 NC_014251:1174674-1174928 [Streptococcus pneumoniae TCH8431/19A]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT24811 WP_000208080.1 NC_014251:1174430-1174672 [Streptococcus pneumoniae TCH8431/19A]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT24811 NC_014251:1174430-1174672 [Streptococcus pneumoniae TCH8431/19A]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7