Detailed information of TA system TA024810

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 3176797..3177094
• Replicon: chromosome
• Accession: NC_014248
• Organism: Nostoc azollae 0708

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AAZO_RS30590
• Protein ID: WP_081462913.1
• Coordinates: 3176797..3176946 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AAZO_RS30595
• Protein ID: WP_081462794.1
• Coordinates: 3176939..3177094 (+)
• Length: 52 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AAZO_RS14695	3173092..3173478	-	387	Protein_2993	VanZ family protein	-
AAZO_RS14700	3173579..3173839	-	261	WP_013191851.1	hypothetical protein	-
AAZO_RS14705	3173917..3174512	-	596	Protein_2995	Uma2 family endonuclease	-
AAZO_RS14710	3174553..3174753	+	201	WP_013191852.1	hypothetical protein	-
AAZO_RS33930	3174907..3174999	-	93	WP_081462793.1	DUF433 domain-containing protein	-
AAZO_RS30585	3175027..3176316	-	1290	Protein_2998	transposase	-
AAZO_RS30590	3176797..3176946	+	150	WP_081462913.1	type II toxin-antitoxin system HicA family toxin	Toxin
AAZO_RS30595	3176939..3177094	+	156	WP_081462794.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AAZO_RS14720	3177872..3180514	-	2643	WP_013191853.1	alanine--tRNA ligase	-
AAZO_RS33935	3181194..3181463	+	270	WP_144031310.1	transposase family protein	-
AAZO_RS33940	3181433..3181585	+	153	WP_144031402.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3171887..3172207	320

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-44)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-49)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5301.11 Da
• Isoelectric Point: 8.0268

>T24810 WP_081462913.1 NC_014248:3176797-3176946 ['Nostoc azollae' 0708]
IECTRGSHRIIKNDNKLGIVVVPGNPSDDILIGTLSSIWKQTKLGAIND

Nucleotide

• Length: 150 bp

>T24810 NC_014248:3176797-3176946 ['Nostoc azollae' 0708]
ATAGAATGCACAAGAGGTAGTCATCGTATAATTAAAAATGACAATAAGTTAGGTATCGTAGTTGTACCTGGAAACCCAAG
TGATGACATTCTAATAGGTACACTTTCATCAATTTGGAAGCAGACAAAATTAGGAGCAATAAATGATTGA

Antitoxin

Protein

• Length: 52 a.a.
• Molecular weight: 5825.62 Da
• Isoelectric Point: 3.7140

>AT24810 WP_081462794.1 NC_014248:3176939-3177094 ['Nostoc azollae' 0708]
MIEYTVIYEPGETNWCAYFPDSPGCVSIGNTLPEVQGNLKEAIEWYLEILK

Nucleotide

• Length: 156 bp

>AT24810 NC_014248:3176939-3177094 ['Nostoc azollae' 0708]
ATGATTGAGTACACAGTCATTTACGAACCTGGTGAGACAAACTGGTGTGCTTATTTTCCCGACTCACCCGGTTGTGTTAG
CATTGGCAATACCTTACCCGAAGTACAGGGAAATCTTAAAGAAGCTATAGAATGGTATTTGGAAATATTGAAATAA