Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1434417..1435015 Replicon chromosome
Accession NC_014246
Organism Mobiluncus curtisii ATCC 43063

Toxin (Protein)


Gene name PumA Uniprot ID D6ZFY9
Locus tag HMPREF0573_RS06015 Protein ID WP_013189226.1
Coordinates 1434417..1434725 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D6ZFZ0
Locus tag HMPREF0573_RS06020 Protein ID WP_004009166.1
Coordinates 1434722..1435015 (+) Length 98 a.a.

Genomic Context

HMPREF0573_RS06015HMPREF0573_RS06020HMPREF0573_RS06035HMPREF0573_RS06005HMPREF0573_RS06010HMPREF0573_RS06025HMPREF0573_RS06030HMPREF0573_RS06040HMPREF0573_RS06045HMPREF0573_RS06050HMPREF0573_RS06055HMPREF0573_RS06060
Location: 1434417..1434725 (309 bp)
Type: Toxin
Protein ID: WP_013189226.1
Location: 1434722..1435015 (294 bp)
Type: Antitoxin
Protein ID: WP_004009166.1
Location: 1436319..1436831 (513 bp)
Type: Others
Protein ID: WP_013189229.1
Location: 1430992..1431678 (687 bp)
Type: Others
Protein ID: WP_013189224.1
Location: 1431683..1434364 (2682 bp)
Type: Others
Protein ID: WP_013189225.1
Location: 1435221..1435625 (405 bp)
Type: Others
Protein ID: WP_013189227.1
Location: 1435647..1436258 (612 bp)
Type: Others
Protein ID: WP_013189228.1
Location: 1436828..1437172 (345 bp)
Type: Others
Protein ID: WP_013189230.1
Location: 1437169..1437606 (438 bp)
Type: Others
Protein ID: WP_013189231.1
Location: 1437606..1437938 (333 bp)
Type: Others
Protein ID: WP_041797999.1
Location: 1437954..1438271 (318 bp)
Type: Others
Protein ID: WP_013189233.1
Location: 1438301..1439521 (1221 bp)
Type: Others
Protein ID: WP_013189234.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HMPREF0573_RS060051430992..1431678-687WP_013189224.1hypothetical protein-
HMPREF0573_RS060101431683..1434364-2682WP_013189225.1tape measure protein-
HMPREF0573_RS060151434417..1434725+309WP_013189226.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HMPREF0573_RS060201434722..1435015+294WP_004009166.1putative addiction module antidote proteinAntitoxin
HMPREF0573_RS060251435221..1435625-405WP_013189227.1hypothetical protein-
HMPREF0573_RS060301435647..1436258-612WP_013189228.1phage tail protein-
HMPREF0573_RS060351436319..1436831+513WP_013189229.1VanZ family protein-
HMPREF0573_RS060401436828..1437172-345WP_013189230.1hypothetical protein-
HMPREF0573_RS060451437169..1437606-438WP_013189231.1HK97 gp10 family phage protein-
HMPREF0573_RS060501437606..1437938-333WP_041797999.1head-tail adaptor protein-
HMPREF0573_RS060551437954..1438271-318WP_013189233.1head-tail connector protein-
HMPREF0573_RS060601438301..1439521-1221WP_013189234.1phage major capsid protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1423431..148059957168


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-97)

Antitoxin

Uncharacterized protein HI1420

(6-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11399.08 Da        Isoelectric Point: 9.8920

>T24809 WP_013189226.1 NC_014246:1434417-1434725 [Mobiluncus curtisii ATCC 43063]
VEIISSSLFDAWLGELKDKHAQRRILHAIARCEAHGTMVGDIKPVGEKVNEMRFHFGPGYRVYYTQLGAVTVFLLAGGDK
SSQAKDIRTAQKLAQQVRKEQS

Download         Length: 309 bp

>T24809 NC_014246:1434417-1434725 [Mobiluncus curtisii ATCC 43063]
GTGGAGATTATTTCTAGTAGCTTGTTTGACGCTTGGTTAGGTGAGCTGAAAGACAAACATGCTCAGCGGCGCATTTTGCA
TGCAATAGCCCGATGCGAAGCACACGGAACAATGGTTGGAGACATCAAACCCGTTGGCGAGAAAGTTAACGAGATGAGAT
TTCATTTCGGGCCCGGCTACCGGGTGTACTACACCCAACTAGGTGCAGTAACGGTTTTCCTGCTGGCCGGAGGAGATAAA
TCCAGCCAGGCTAAAGACATTCGAACCGCTCAAAAGCTCGCACAACAGGTAAGGAAGGAACAGTCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10642.17 Da        Isoelectric Point: 7.0095

>AT24809 WP_004009166.1 NC_014246:1434722-1435015 [Mobiluncus curtisii ATCC 43063]
MKEVTFSAFDASKYLDSQEAMNDYLAIALEDGDTKTVQVVLRDIARAHGMSQLAKETQLNRESLYKSLSKDGNPSFAAIT
KIMKALGLKITLATQNA

Download         Length: 294 bp

>AT24809 NC_014246:1434722-1435015 [Mobiluncus curtisii ATCC 43063]
ATGAAGGAAGTAACATTTTCAGCGTTCGACGCAAGCAAATATCTCGATAGCCAAGAAGCAATGAACGATTACCTAGCTAT
CGCACTCGAAGACGGCGATACGAAAACCGTACAGGTGGTTTTGCGTGACATTGCAAGGGCACACGGCATGAGCCAGCTAG
CTAAAGAAACTCAACTCAACCGTGAATCCCTCTACAAGTCACTATCAAAAGACGGCAACCCGTCCTTTGCGGCTATCACG
AAAATCATGAAAGCCCTAGGACTCAAAATAACTCTCGCTACACAAAATGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2N6UZ62

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0K1RCQ5

References