Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1434417..1435015 Replicon chromosome
Accession NC_014246
Organism Mobiluncus curtisii ATCC 43063

Toxin (Protein)


Gene name PumA Uniprot ID D6ZFY9
Locus tag HMPREF0573_RS06015 Protein ID WP_013189226.1
Coordinates 1434417..1434725 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D6ZFZ0
Locus tag HMPREF0573_RS06020 Protein ID WP_004009166.1
Coordinates 1434722..1435015 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0573_RS06005 1430992..1431678 - 687 WP_013189224.1 hypothetical protein -
HMPREF0573_RS06010 1431683..1434364 - 2682 WP_013189225.1 tape measure protein -
HMPREF0573_RS06015 1434417..1434725 + 309 WP_013189226.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HMPREF0573_RS06020 1434722..1435015 + 294 WP_004009166.1 putative addiction module antidote protein Antitoxin
HMPREF0573_RS06025 1435221..1435625 - 405 WP_013189227.1 hypothetical protein -
HMPREF0573_RS06030 1435647..1436258 - 612 WP_013189228.1 phage tail protein -
HMPREF0573_RS06035 1436319..1436831 + 513 WP_013189229.1 VanZ family protein -
HMPREF0573_RS06040 1436828..1437172 - 345 WP_013189230.1 hypothetical protein -
HMPREF0573_RS06045 1437169..1437606 - 438 WP_013189231.1 HK97 gp10 family phage protein -
HMPREF0573_RS06050 1437606..1437938 - 333 WP_041797999.1 head-tail adaptor protein -
HMPREF0573_RS06055 1437954..1438271 - 318 WP_013189233.1 head-tail connector protein -
HMPREF0573_RS06060 1438301..1439521 - 1221 WP_013189234.1 phage major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1423431..1480599 57168


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-97)

Antitoxin

Uncharacterized protein HI1420

(6-92)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11399.08 Da        Isoelectric Point: 9.8920

>T24809 WP_013189226.1 NC_014246:1434417-1434725 [Mobiluncus curtisii ATCC 43063]
VEIISSSLFDAWLGELKDKHAQRRILHAIARCEAHGTMVGDIKPVGEKVNEMRFHFGPGYRVYYTQLGAVTVFLLAGGDK
SSQAKDIRTAQKLAQQVRKEQS

Download         Length: 309 bp

>T24809 NC_014246:1434417-1434725 [Mobiluncus curtisii ATCC 43063]
GTGGAGATTATTTCTAGTAGCTTGTTTGACGCTTGGTTAGGTGAGCTGAAAGACAAACATGCTCAGCGGCGCATTTTGCA
TGCAATAGCCCGATGCGAAGCACACGGAACAATGGTTGGAGACATCAAACCCGTTGGCGAGAAAGTTAACGAGATGAGAT
TTCATTTCGGGCCCGGCTACCGGGTGTACTACACCCAACTAGGTGCAGTAACGGTTTTCCTGCTGGCCGGAGGAGATAAA
TCCAGCCAGGCTAAAGACATTCGAACCGCTCAAAAGCTCGCACAACAGGTAAGGAAGGAACAGTCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10642.17 Da        Isoelectric Point: 7.0095

>AT24809 WP_004009166.1 NC_014246:1434722-1435015 [Mobiluncus curtisii ATCC 43063]
MKEVTFSAFDASKYLDSQEAMNDYLAIALEDGDTKTVQVVLRDIARAHGMSQLAKETQLNRESLYKSLSKDGNPSFAAIT
KIMKALGLKITLATQNA

Download         Length: 294 bp

>AT24809 NC_014246:1434722-1435015 [Mobiluncus curtisii ATCC 43063]
ATGAAGGAAGTAACATTTTCAGCGTTCGACGCAAGCAAATATCTCGATAGCCAAGAAGCAATGAACGATTACCTAGCTAT
CGCACTCGAAGACGGCGATACGAAAACCGTACAGGTGGTTTTGCGTGACATTGCAAGGGCACACGGCATGAGCCAGCTAG
CTAAAGAAACTCAACTCAACCGTGAATCCCTCTACAAGTCACTATCAAAAGACGGCAACCCGTCCTTTGCGGCTATCACG
AAAATCATGAAAGCCCTAGGACTCAAAATAACTCTCGCTACACAAAATGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N6UZ62

Antitoxin

Source ID Structure
AlphaFold DB A0A0K1RCQ5

References