Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 215650..216176 Replicon plasmid pYQ13422-1
Accession NZ_CP098779
Organism Enterobacter hormaechei strain YQ13422hy

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ND013_RS22965 Protein ID WP_000323025.1
Coordinates 215650..215937 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ND013_RS22970 Protein ID WP_000534858.1
Coordinates 215937..216176 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND013_RS22930 211220..211396 - 177 WP_001371930.1 hypothetical protein -
ND013_RS22935 211907..212851 + 945 WP_000778029.1 DUF5417 domain-containing protein -
ND013_RS22940 212947..213549 + 603 WP_012695474.1 hypothetical protein -
ND013_RS22945 213609..213959 + 351 WP_000743059.1 hypothetical protein -
ND013_RS22950 214006..214209 + 204 WP_001015183.1 hypothetical protein -
ND013_RS22955 214491..214811 + 321 WP_000332796.1 hypothetical protein -
ND013_RS22960 215424..215549 - 126 WP_229020258.1 DUF5431 family protein -
ND013_RS22965 215650..215937 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ND013_RS22970 215937..216176 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ND013_RS22975 216201..216305 + 105 Protein_229 protein YdfV -
ND013_RS22980 216439..217362 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
ND013_RS22985 217562..218134 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
ND013_RS22990 218610..219848 - 1239 WP_000219087.1 IS110-like element ISEsa2 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / aac(3)-IId / blaTEM-1B / blaSFO-1 / catA2 / tet(D) / blaSHV-12 / sul1 / blaDHA-1 / qnrB4 / qacE / ere(A) / aac(6')-IIc - 1..295136 295136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T248089 WP_000323025.1 NZ_CP098779:c215937-215650 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT248089 WP_000534858.1 NZ_CP098779:c216176-215937 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References