Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4487663..4488279 Replicon chromosome
Accession NZ_CP098778
Organism Enterobacter hormaechei strain YQ13422hy

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ND013_RS21435 Protein ID WP_077266491.1
Coordinates 4487663..4488034 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag ND013_RS21440 Protein ID WP_015569912.1
Coordinates 4488037..4488279 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND013_RS21420 4485163..4486065 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
ND013_RS21425 4486062..4486697 + 636 WP_126499207.1 formate dehydrogenase cytochrome b556 subunit -
ND013_RS21430 4486694..4487623 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
ND013_RS21435 4487663..4488034 - 372 WP_077266491.1 type II toxin-antitoxin system VapC family toxin Toxin
ND013_RS21440 4488037..4488279 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
ND013_RS21445 4488478..4489398 + 921 WP_126499206.1 alpha/beta hydrolase -
ND013_RS21450 4489407..4490348 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
ND013_RS21455 4490393..4490830 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
ND013_RS21460 4490827..4491708 - 882 WP_003861949.1 virulence factor BrkB family protein -
ND013_RS21465 4491702..4492301 - 600 WP_017694048.1 glucose-1-phosphatase -
ND013_RS21470 4492420..4493220 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13723.85 Da        Isoelectric Point: 6.4882

>T248087 WP_077266491.1 NZ_CP098778:c4488034-4487663 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT248087 WP_015569912.1 NZ_CP098778:c4488279-4488037 [Enterobacter hormaechei]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References