Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2297222..2297961 Replicon chromosome
Accession NZ_CP098778
Organism Enterobacter hormaechei strain YQ13422hy

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag ND013_RS11110 Protein ID WP_110293091.1
Coordinates 2297222..2297707 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag ND013_RS11115 Protein ID WP_003857131.1
Coordinates 2297695..2297961 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND013_RS11085 2292763..2293521 - 759 WP_126498540.1 trans-aconitate 2-methyltransferase -
ND013_RS11090 2293606..2294190 - 585 WP_126498541.1 NUDIX domain-containing protein -
ND013_RS11095 2294277..2295035 + 759 WP_015570520.1 DeoR/GlpR family DNA-binding transcription regulator -
ND013_RS11100 2295140..2296432 + 1293 WP_126498542.1 glycosyl hydrolase family 28 protein -
ND013_RS11105 2296432..2297046 + 615 WP_080338042.1 NUDIX hydrolase -
ND013_RS11110 2297222..2297707 - 486 WP_110293091.1 GNAT family N-acetyltransferase Toxin
ND013_RS11115 2297695..2297961 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
ND013_RS11120 2298025..2298954 - 930 WP_110293092.1 LysR family transcriptional regulator -
ND013_RS11125 2299083..2300471 + 1389 WP_126498675.1 MFS transporter -
ND013_RS11130 2300494..2301489 - 996 WP_110293093.1 DUF2891 domain-containing protein -
ND013_RS11135 2301499..2302485 - 987 WP_110293094.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2287193..2297961 10768


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(35-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17544.24 Da        Isoelectric Point: 9.9658

>T248079 WP_110293091.1 NZ_CP098778:c2297707-2297222 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIVLARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAMMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT248079 WP_003857131.1 NZ_CP098778:c2297961-2297695 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References