Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1689382..1690179 Replicon chromosome
Accession NZ_CP098778
Organism Enterobacter hormaechei strain YQ13422hy

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag ND013_RS07990 Protein ID WP_126498947.1
Coordinates 1689658..1690179 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID F5RT92
Locus tag ND013_RS07985 Protein ID WP_001303459.1
Coordinates 1689382..1689651 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND013_RS07950 1685095..1685976 + 882 WP_040117471.1 DUF6402 family protein -
ND013_RS07955 1685973..1686404 + 432 WP_050597034.1 DUF6201 family protein -
ND013_RS07960 1686557..1686658 + 102 Protein_1543 type VI secretion system lipoprotein TssJ -
ND013_RS07965 1686882..1687109 - 228 WP_006809324.1 YccJ family protein -
ND013_RS07970 1687128..1687724 - 597 WP_126498949.1 NAD(P)H:quinone oxidoreductase -
ND013_RS07975 1688116..1688286 + 171 WP_001273664.1 general stress protein -
ND013_RS07980 1688403..1689308 + 906 WP_126498948.1 DMT family transporter -
ND013_RS07985 1689382..1689651 + 270 WP_001303459.1 DUF1778 domain-containing protein Antitoxin
ND013_RS07990 1689658..1690179 + 522 WP_126498947.1 GNAT family N-acetyltransferase Toxin
ND013_RS07995 1690238..1691560 - 1323 WP_126498946.1 pyrimidine utilization transport protein G -
ND013_RS08000 1691582..1692073 - 492 WP_246893580.1 pyrimidine utilization flavin reductase protein F -
ND013_RS08005 1692086..1692676 - 591 WP_047052687.1 malonic semialdehyde reductase -
ND013_RS08010 1692686..1693486 - 801 WP_047717625.1 pyrimidine utilization protein D -
ND013_RS08015 1693494..1693880 - 387 WP_126498945.1 pyrimidine utilization protein C -
ND013_RS08020 1693892..1694581 - 690 WP_126498944.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(89-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19438.13 Da        Isoelectric Point: 7.4318

>T248078 WP_126498947.1 NZ_CP098778:1689658-1690179 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTEHLVRQHGGRNLRGYLLKERDHPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10248.70 Da        Isoelectric Point: 5.8836

>AT248078 WP_001303459.1 NZ_CP098778:1689382-1689651 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7D7BCZ2

References