Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 3874773..3875358 Replicon chromosome
Accession NZ_CP098777
Organism Cronobacter sakazakii strain JXES-28

Toxin (Protein)


Gene name PumA Uniprot ID A0A853H7C5
Locus tag NES82_RS18815 Protein ID WP_014727945.1
Coordinates 3874773..3875078 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2S9UB62
Locus tag NES82_RS18820 Protein ID WP_007852536.1
Coordinates 3875083..3875358 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NES82_RS18790 (NES82_18795) 3870804..3872396 + 1593 WP_161574667.1 RNA repair transcriptional activator RtcR -
NES82_RS18795 (NES82_18800) 3872558..3873493 + 936 WP_004387518.1 ketopantoate/pantoate/pantothenate transporter PanS -
NES82_RS18800 (NES82_18805) 3873584..3873856 + 273 WP_007702377.1 DUF3811 domain-containing protein -
NES82_RS18805 (NES82_18810) 3873871..3874209 - 339 WP_161574668.1 helix-turn-helix transcriptional regulator -
NES82_RS18810 (NES82_18815) 3874206..3874556 - 351 WP_007852532.1 type II toxin-antitoxin system RelE/ParE family toxin -
NES82_RS18815 (NES82_18820) 3874773..3875078 + 306 WP_014727945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NES82_RS18820 (NES82_18825) 3875083..3875358 + 276 WP_007852536.1 putative addiction module antidote protein Antitoxin
NES82_RS18825 (NES82_18830) 3875375..3877006 - 1632 WP_007852537.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11588.58 Da        Isoelectric Point: 10.3395

>T248073 WP_014727945.1 NZ_CP098777:3874773-3875078 [Cronobacter sakazakii]
MKHIFQTEVFRRWQASLKDQRVKTMIAARLFRLANGLPGDVKPVGAGISELRIHYGAGYRIYFKQHGEVIVILLCGGDKH
TQDKDILLAKMLADLPENQWR

Download         Length: 306 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9597.06 Da        Isoelectric Point: 6.4609

>AT248073 WP_007852536.1 NZ_CP098777:3875083-3875358 [Cronobacter sakazakii]
MKLTEYDPAAALVDDEEIAFFMADALETGDAGHIAKALGVVARAKGMSHIAAQTGLSREQLYRSFSDKGNPTLKTTLAVM
KALGLGLTVKS

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853H7C5

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9UB62

References