248072

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 3873871..3874556 Replicon chromosome
Accession NZ_CP098777
Organism Cronobacter sakazakii strain JXES-28

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag NES82_RS18810 Protein ID WP_007852532.1
Coordinates 3874206..3874556 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag NES82_RS18805 Protein ID WP_161574668.1
Coordinates 3873871..3874209 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NES82_RS18785 (NES82_18790) 3869195..3870328 - 1134 WP_007871440.1 slipin family protein -
NES82_RS18790 (NES82_18795) 3870804..3872396 + 1593 WP_161574667.1 RNA repair transcriptional activator RtcR -
NES82_RS18795 (NES82_18800) 3872558..3873493 + 936 WP_004387518.1 ketopantoate/pantoate/pantothenate transporter PanS -
NES82_RS18800 (NES82_18805) 3873584..3873856 + 273 WP_007702377.1 DUF3811 domain-containing protein -
NES82_RS18805 (NES82_18810) 3873871..3874209 - 339 WP_161574668.1 helix-turn-helix transcriptional regulator Antitoxin
NES82_RS18810 (NES82_18815) 3874206..3874556 - 351 WP_007852532.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NES82_RS18815 (NES82_18820) 3874773..3875078 + 306 WP_014727945.1 type II toxin-antitoxin system RelE/ParE family toxin -
NES82_RS18820 (NES82_18825) 3875083..3875358 + 276 WP_007852536.1 putative addiction module antidote protein -
NES82_RS18825 (NES82_18830) 3875375..3877006 - 1632 WP_007852537.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.99 Da        Isoelectric Point: 10.2932

>T248072 WP_007852532.1 NZ_CP098777:c3874556-3874206 [Cronobacter sakazakii]
MIKPLFWVGQARKDLQALPEDVQDLFGYALYLAQQGRRHPQARPLKGFGGAGVLEVVEDYQGNAFRAVYTVRLGEAIYVL
HVFQKKSSSGIATPRPEMEKIEQRLKAAQRHAGGLK

Download         Length: 351 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12362.53 Da        Isoelectric Point: 9.0266

>AT248072 WP_161574668.1 NZ_CP098777:c3874209-3873871 [Cronobacter sakazakii]
MTADIERSNGNVYDDLGLIDAEEMQLKAQLAMAISDILKARGLTQQEAARLLGMTQPKLSLLLRGQFRGISETKMMACLM
LLGRDISIVVGEAQQARGKMRLIYQPPEKGRA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References