Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3515600..3516263 Replicon chromosome
Accession NZ_CP098777
Organism Cronobacter sakazakii strain JXES-28

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag NES82_RS17110 Protein ID WP_097564054.1
Coordinates 3515600..3516016 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3Q9CFW7
Locus tag NES82_RS17115 Protein ID WP_007870701.1
Coordinates 3515997..3516263 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NES82_RS17090 (NES82_17095) 3511588..3513321 - 1734 WP_007870697.1 single-stranded-DNA-specific exonuclease RecJ -
NES82_RS17095 (NES82_17100) 3513325..3514044 - 720 WP_004385678.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NES82_RS17100 (NES82_17105) 3514067..3514963 - 897 WP_161574673.1 site-specific tyrosine recombinase XerD -
NES82_RS17105 (NES82_17110) 3515065..3515586 + 522 WP_004385676.1 flavodoxin FldB -
NES82_RS17110 (NES82_17115) 3515600..3516016 - 417 WP_097564054.1 protein YgfX Toxin
NES82_RS17115 (NES82_17120) 3515997..3516263 - 267 WP_007870701.1 FAD assembly factor SdhE Antitoxin
NES82_RS17120 (NES82_17125) 3516541..3517530 + 990 WP_069681646.1 tRNA-modifying protein YgfZ -
NES82_RS17125 (NES82_17130) 3517635..3518288 - 654 WP_007777939.1 hemolysin III family protein -
NES82_RS17130 (NES82_17135) 3518431..3518745 - 315 WP_069681647.1 N(4)-acetylcytidine aminohydrolase -
NES82_RS17135 (NES82_17140) 3518921..3519649 + 729 WP_032805608.1 MurR/RpiR family transcriptional regulator -
NES82_RS17140 (NES82_17145) 3519801..3521234 + 1434 WP_161574592.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16388.39 Da        Isoelectric Point: 10.8220

>T248070 WP_097564054.1 NZ_CP098777:c3516016-3515600 [Cronobacter sakazakii]
VVLWHSDLRVSWRSQWLSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYHLRWQGV
DWQICATPWMLRSGMMLRLRHPKTTRCHHVWLAADSMTEAEWRDLRRLLLQQPVGDKR

Download         Length: 417 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.89 Da        Isoelectric Point: 4.8310

>AT248070 WP_007870701.1 NZ_CP098777:c3516263-3515997 [Cronobacter sakazakii]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSDEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVELIQQRN
QARGPVAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CFW7

References