Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1094535..1095154 Replicon chromosome
Accession NZ_CP098777
Organism Cronobacter sakazakii strain JXES-28

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S9UIC9
Locus tag NES82_RS05645 Protein ID WP_004386909.1
Coordinates 1094535..1094753 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q9CL77
Locus tag NES82_RS05650 Protein ID WP_004386908.1
Coordinates 1094780..1095154 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NES82_RS05620 (NES82_05625) 1090673..1092574 + 1902 WP_038881338.1 methyl-accepting chemotaxis protein -
NES82_RS05625 (NES82_05630) 1092714..1092974 + 261 WP_032973087.1 type B 50S ribosomal protein L31 -
NES82_RS05630 (NES82_05635) 1092978..1093118 + 141 WP_004386911.1 type B 50S ribosomal protein L36 -
NES82_RS05635 (NES82_05640) 1093147..1093656 - 510 WP_161574205.1 YlaC family protein -
NES82_RS05640 (NES82_05645) 1093777..1094328 - 552 WP_004386910.1 maltose O-acetyltransferase -
NES82_RS05645 (NES82_05650) 1094535..1094753 - 219 WP_004386909.1 HHA domain-containing protein Toxin
NES82_RS05650 (NES82_05655) 1094780..1095154 - 375 WP_004386908.1 Hha toxicity modulator TomB Antitoxin
NES82_RS05655 (NES82_05660) 1095616..1098765 - 3150 WP_007848020.1 multidrug efflux RND transporter permease subunit AcrB -
NES82_RS05660 (NES82_05665) 1098787..1099992 - 1206 WP_007848022.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8598.02 Da        Isoelectric Point: 9.4828

>T248060 WP_004386909.1 NZ_CP098777:c1094753-1094535 [Cronobacter sakazakii]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14343.05 Da        Isoelectric Point: 4.7168

>AT248060 WP_004386908.1 NZ_CP098777:c1095154-1094780 [Cronobacter sakazakii]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHEDDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASKENPVSLSF

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9UIC9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CL77

References