Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 138131..139734 Replicon plasmid unnamed1
Accession NZ_CP098775
Organism Cronobacter sakazakii strain JXES-28

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NES82_RS00570 Protein ID WP_097566363.1
Coordinates 138131..139450 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NES82_RS00575 Protein ID WP_063265894.1
Coordinates 139453..139734 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NES82_RS00560 (NES82_00560) 133513..136044 - 2532 WP_161575012.1 malto-oligosyltrehalose synthase -
NES82_RS00565 (NES82_00565) 136041..137825 - 1785 WP_038878178.1 malto-oligosyltrehalose trehalohydrolase -
NES82_RS00570 (NES82_00570) 138131..139450 - 1320 WP_097566363.1 type II toxin-antitoxin system HipA family toxin Toxin
NES82_RS00575 (NES82_00575) 139453..139734 - 282 WP_063265894.1 helix-turn-helix transcriptional regulator Antitoxin
NES82_RS00580 (NES82_00580) 139865..140749 - 885 WP_085046093.1 siderophore-interacting protein -
NES82_RS00585 (NES82_00585) 140746..141957 - 1212 WP_161575013.1 MFS transporter -
NES82_RS00590 (NES82_00590) 142093..143841 + 1749 WP_161575014.1 IucA/IucC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH / mgtB / iucA / iucB / iucC / iutA 1..153659 153659


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(153-404)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49083.07 Da        Isoelectric Point: 7.0032

>T248059 WP_097566363.1 NZ_CP098775:c139450-138131 [Cronobacter sakazakii]
MRRTSRLALWMNGIPVGYWDKHNGEDRLTYLPEWIADPQGRPLSLSLPFTPGNQSYRGAQVRDYFDNLLPDSENIRRRLA
MRYRAQSLEPFDLLAELGRDCVGAIQLLPAGEAPEGLFTIRARPLSTVDIAAMLRHTAEAFPGQHGGEEELRLSIAGAQE
KTALLWHEDQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCAQLLAAWDIPVARTQMAQFEEQKVLIVERFDR
RLSGDGRWWLRLPQEDMCQALGVSPLRKYQADGGPGIGDIMTVLSRSENAQADRANFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNNQIAWQKCKLAMAVRGSSNYYHLSQIRRRHWLRQGELAGLSAAQVNDMIDALTA
SAPAVIARVADALPVDFPASLADVIFNGMRQQCARLAAA

Download         Length: 1320 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10519.00 Da        Isoelectric Point: 9.8007

>AT248059 WP_063265894.1 NZ_CP098775:c139734-139453 [Cronobacter sakazakii]
MNTRYPLKTLSQLRPLLVGFRKKQGLTQKEVSARLGVTQQTYARLEANPETASIERLFRVFNVLGIEITLCETQAAESDA
PARDDSPARREAW

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References