Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5113259..5114940 Replicon chromosome
Accession NZ_CP098770
Organism Klebsiella pneumoniae strain TH12845

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NE242_RS25265 Protein ID WP_002885155.1
Coordinates 5113259..5114176 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NE242_RS25270 Protein ID WP_004151732.1
Coordinates 5114182..5114940 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE242_RS25245 (NE242_25245) 5108565..5110085 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NE242_RS25250 (NE242_25250) 5110082..5111080 + 999 WP_002885172.1 ribose ABC transporter permease -
NE242_RS25255 (NE242_25255) 5111111..5112052 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NE242_RS25260 (NE242_25260) 5112127..5113134 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NE242_RS25265 (NE242_25265) 5113259..5114176 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NE242_RS25270 (NE242_25270) 5114182..5114940 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NE242_RS25275 (NE242_25275) 5115026..5115754 - 729 WP_002885152.1 response regulator transcription factor -
NE242_RS25280 (NE242_25280) 5116027..5118174 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NE242_RS25285 (NE242_25285) 5118404..5119090 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T248054 WP_002885155.1 NZ_CP098770:c5114176-5113259 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT248054 WP_004151732.1 NZ_CP098770:c5114940-5114182 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References