Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4758832..4759642 Replicon chromosome
Accession NZ_CP098770
Organism Klebsiella pneumoniae strain TH12845

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NE242_RS23475 Protein ID WP_002887280.1
Coordinates 4758832..4759365 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NE242_RS23480 Protein ID WP_002887278.1
Coordinates 4759376..4759642 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE242_RS23470 (NE242_23470) 4757663..4758784 + 1122 WP_002887282.1 cupin domain-containing protein -
NE242_RS23475 (NE242_23475) 4758832..4759365 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NE242_RS23480 (NE242_23480) 4759376..4759642 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NE242_RS23485 (NE242_23485) 4759745..4761178 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
NE242_RS23490 (NE242_23490) 4761168..4761851 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NE242_RS23495 (NE242_23495) 4762023..4763408 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
NE242_RS23500 (NE242_23500) 4763426..4763770 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(91-151)

Antitoxin

(2-86)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T248052 WP_002887280.1 NZ_CP098770:c4759365-4758832 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT248052 WP_002887278.1 NZ_CP098770:c4759642-4759376 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN


Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References