Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2751246..2752834 Replicon chromosome
Accession NZ_CP098770
Organism Klebsiella pneumoniae strain TH12845

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NE242_RS13645 Protein ID WP_004199851.1
Coordinates 2751246..2752568 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NE242_RS13650 Protein ID WP_002904790.1
Coordinates 2752568..2752834 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE242_RS13630 (NE242_13630) 2746311..2748812 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
NE242_RS13635 (NE242_13635) 2748800..2749804 + 1005 WP_004199852.1 fimbrial protein -
NE242_RS13640 (NE242_13640) 2749937..2751229 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NE242_RS13645 (NE242_13645) 2751246..2752568 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NE242_RS13650 (NE242_13650) 2752568..2752834 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NE242_RS13655 (NE242_13655) 2753100..2753426 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NE242_RS13660 (NE242_13660) 2753423..2753923 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NE242_RS13665 (NE242_13665) 2753901..2755280 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
NE242_RS13670 (NE242_13670) 2755626..2756780 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NE242_RS13675 (NE242_13675) 2756761..2757684 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T248050 WP_004199851.1 NZ_CP098770:c2752568-2751246 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT248050 WP_002904790.1 NZ_CP098770:c2752834-2752568 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References