Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4964414..4966095 Replicon chromosome
Accession NZ_CP098769
Organism Klebsiella pneumoniae strain TH12846

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NE243_RS24505 Protein ID WP_002885155.1
Coordinates 4964414..4965331 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NE243_RS24510 Protein ID WP_004151732.1
Coordinates 4965337..4966095 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE243_RS24485 (NE243_24485) 4959720..4961240 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NE243_RS24490 (NE243_24490) 4961237..4962235 + 999 WP_002885172.1 ribose ABC transporter permease -
NE243_RS24495 (NE243_24495) 4962266..4963207 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NE243_RS24500 (NE243_24500) 4963282..4964289 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NE243_RS24505 (NE243_24505) 4964414..4965331 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NE243_RS24510 (NE243_24510) 4965337..4966095 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NE243_RS24515 (NE243_24515) 4966181..4966909 - 729 WP_002885152.1 response regulator transcription factor -
NE243_RS24520 (NE243_24520) 4967182..4969329 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NE243_RS24525 (NE243_24525) 4969559..4970245 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T248040 WP_002885155.1 NZ_CP098769:c4965331-4964414 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT248040 WP_004151732.1 NZ_CP098769:c4966095-4965337 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References