Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4704940..4705750 Replicon chromosome
Accession NZ_CP098769
Organism Klebsiella pneumoniae strain TH12846

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NE243_RS23210 Protein ID WP_002887280.1
Coordinates 4704940..4705473 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NE243_RS23215 Protein ID WP_002887278.1
Coordinates 4705484..4705750 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE243_RS23205 (NE243_23205) 4703771..4704892 + 1122 WP_002887282.1 cupin domain-containing protein -
NE243_RS23210 (NE243_23210) 4704940..4705473 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NE243_RS23215 (NE243_23215) 4705484..4705750 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NE243_RS23220 (NE243_23220) 4705853..4707286 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
NE243_RS23225 (NE243_23225) 4707276..4707959 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NE243_RS23230 (NE243_23230) 4708131..4709516 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
NE243_RS23235 (NE243_23235) 4709534..4709878 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T248038 WP_002887280.1 NZ_CP098769:c4705473-4704940 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT248038 WP_002887278.1 NZ_CP098769:c4705750-4705484 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References