Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876817..877471 Replicon chromosome
Accession NZ_CP098769
Organism Klebsiella pneumoniae strain TH12846

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag NE243_RS04435 Protein ID WP_004144731.1
Coordinates 877064..877471 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NE243_RS04430 Protein ID WP_002916312.1
Coordinates 876817..877083 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE243_RS04405 (NE243_04405) 871973..873406 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NE243_RS04410 (NE243_04410) 873525..874253 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NE243_RS04415 (NE243_04415) 874303..874614 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NE243_RS04420 (NE243_04420) 874778..875437 + 660 WP_002916317.1 hemolysin III family protein -
NE243_RS04425 (NE243_04425) 875588..876571 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NE243_RS04430 (NE243_04430) 876817..877083 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NE243_RS04435 (NE243_04435) 877064..877471 + 408 WP_004144731.1 protein YgfX Toxin
NE243_RS04440 (NE243_04440) 877478..877999 - 522 WP_002916308.1 flavodoxin FldB -
NE243_RS04445 (NE243_04445) 878100..878996 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NE243_RS04450 (NE243_04450) 879019..879731 + 713 Protein_875 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NE243_RS04455 (NE243_04455) 879737..881468 + 1732 Protein_876 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T248031 WP_004144731.1 NZ_CP098769:877064-877471 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT248031 WP_002916312.1 NZ_CP098769:876817-877083 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References