248027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 243938..244497 Replicon chromosome
Accession NZ_CP098767
Organism Brucella melitensis strain 6144

Toxin (Protein)


Gene name brnT Uniprot ID A0A7U8PD14
Locus tag NEE11_RS06840 Protein ID WP_002966807.1
Coordinates 244252..244497 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID C0RIV1
Locus tag NEE11_RS06835 Protein ID WP_004683740.1
Coordinates 243938..244252 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NEE11_RS06785 (NEE11_06785) 239643..239846 - 204 WP_004683737.1 hypothetical protein -
NEE11_RS06790 (NEE11_06790) 239849..240064 - 216 WP_005968947.1 hypothetical protein -
NEE11_RS06795 (NEE11_06795) 240061..240264 - 204 WP_002964088.1 hypothetical protein -
NEE11_RS06800 (NEE11_06800) 240314..241018 + 705 WP_005968944.1 hypothetical protein -
NEE11_RS06805 (NEE11_06805) 241015..241245 + 231 WP_002964091.1 hypothetical protein -
NEE11_RS06810 (NEE11_06810) 241242..241517 + 276 WP_002964092.1 hypothetical protein -
NEE11_RS06815 (NEE11_06815) 241609..242016 + 408 WP_002971458.1 hypothetical protein -
NEE11_RS06820 (NEE11_06820) 242362..243072 + 711 WP_004683739.1 porin family protein -
NEE11_RS06825 (NEE11_06825) 243420..243590 - 171 WP_002964095.1 DUF1508 domain-containing protein -
NEE11_RS06830 (NEE11_06830) 243589..243822 + 234 WP_002969999.1 hypothetical protein -
NEE11_RS06835 (NEE11_06835) 243938..244252 - 315 WP_004683740.1 BrnA antitoxin family protein Antitoxin
NEE11_RS06840 (NEE11_06840) 244252..244497 - 246 WP_002966807.1 BrnT family toxin Toxin
NEE11_RS06845 (NEE11_06845) 244630..245268 + 639 Protein_248 tRNA guanosine transglycosylase -
NEE11_RS06850 (NEE11_06850) 245338..246096 + 759 Protein_249 IS5 family transposase -
NEE11_RS06855 (NEE11_06855) 246097..246870 + 774 Protein_250 hypothetical protein -
NEE11_RS06860 (NEE11_06860) 247201..248652 + 1452 WP_006135932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - wboA / wbdA 237871..251968 14097
- flank IS/Tn - - 245338..245706 368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-78)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9162.82 Da        Isoelectric Point: 10.3158

>T248027 WP_002966807.1 NZ_CP098767:c244497-244252 [Brucella melitensis]
MKIIWDEPKRQTNIAKHGLDFADLHFEFFLSAKVFPTKADRLMAIGEFNGLIIIAVIFKPVGSEALSVISMRSASQKERK
L

Download         Length: 246 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11653.48 Da        Isoelectric Point: 10.5824

>AT248027 WP_004683740.1 NZ_CP098767:c244252-243938 [Brucella melitensis]
MGIKFSSKRPLTQEEEAEIQKMIASDPDAPEATDKQLAKAKPFKESFPDMAAKMEKAIRGRPRIDNPKTPVTIRLDQDVV
QRFKATGKGWQGRMNDALRKAVGL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8PD14

Antitoxin

Source ID Structure
AlphaFold DB C0RIV1

References