Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4656..5236 Replicon plasmid pKP167-10
Accession NZ_CP098761
Organism Klebsiella pneumoniae strain KP167

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag ND678_RS27760 Protein ID WP_071177730.1
Coordinates 4656..4970 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag ND678_RS27765 Protein ID WP_000093040.1
Coordinates 4958..5236 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND678_RS27735 (ND678_27725) 600..2564 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
ND678_RS27740 (ND678_27730) 2564..3295 + 732 WP_071177728.1 MobC family replication-relaxation protein -
ND678_RS27745 (ND678_27735) 3302..3832 + 531 WP_071177729.1 hypothetical protein -
ND678_RS27750 (ND678_27740) 3859..4038 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
ND678_RS27755 (ND678_27745) 4064..4492 - 429 WP_001140599.1 hypothetical protein -
ND678_RS27760 (ND678_27750) 4656..4970 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND678_RS27765 (ND678_27755) 4958..5236 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
ND678_RS27770 (ND678_27760) 5411..5776 - 366 WP_072354022.1 TonB family protein -
ND678_RS27775 (ND678_27765) 5773..6144 - 372 WP_001237044.1 cell envelope integrity protein TolA -
ND678_RS27780 (ND678_27770) 6418..6663 - 246 WP_032440458.1 hypothetical protein -
ND678_RS27785 (ND678_27775) 6990..8675 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
ND678_RS27790 (ND678_27780) 8685..8942 + 258 WP_032440455.1 colicin E3-like toxin immunity protein -
ND678_RS27795 (ND678_27785) 9027..9176 + 150 WP_032440454.1 colicin release lysis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T248025 WP_071177730.1 NZ_CP098761:c4970-4656 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT248025 WP_000093040.1 NZ_CP098761:c5236-4958 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References