Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 200863..201599 Replicon plasmid pKP167-261
Accession NZ_CP098759
Organism Klebsiella pneumoniae strain KP167

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag ND678_RS26855 Protein ID WP_004187044.1
Coordinates 201117..201599 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag ND678_RS26850 Protein ID WP_003026799.1
Coordinates 200863..201129 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND678_RS26835 (ND678_26825) 196335..197729 + 1395 WP_032439652.1 cytosine permease -
ND678_RS26840 (ND678_26830) 197741..198949 + 1209 WP_032448288.1 imidazolonepropionase -
ND678_RS26845 (ND678_26835) 198942..199751 + 810 WP_023329017.1 N-formylglutamate deformylase -
ND678_RS26850 (ND678_26840) 200863..201129 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
ND678_RS26855 (ND678_26845) 201117..201599 + 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
ND678_RS26860 (ND678_26850) 201810..203156 + 1347 WP_077251107.1 ISNCY family transposase -
ND678_RS26865 (ND678_26855) 203316..204020 + 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
ND678_RS26870 (ND678_26860) 204297..205643 + 1347 WP_077254728.1 ISNCY family transposase -
ND678_RS26875 (ND678_26865) 205692..206090 + 399 WP_032422684.1 helix-turn-helix domain-containing protein -
ND678_RS26880 (ND678_26870) 206238..206348 - 111 Protein_218 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid dfrA14 / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR iutA / iucD / iucC / iucB / iucA 1..261525 261525
- inside Integron dfrA14 / ant(3'')-Ia / cmlA1 / ARR-2 / blaOXA-10 iutA / iucD / iucC / iucB / iucA 53..261411 261358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T248020 WP_004187044.1 NZ_CP098759:201117-201599 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT248020 WP_003026799.1 NZ_CP098759:200863-201129 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References