Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4433118..4434706 Replicon chromosome
Accession NZ_CP098758
Organism Klebsiella pneumoniae strain KP167

Toxin (Protein)


Gene name hipA Uniprot ID A0A486MZ73
Locus tag ND678_RS21395 Protein ID WP_009485244.1
Coordinates 4433384..4434706 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag ND678_RS21390 Protein ID WP_002904790.1
Coordinates 4433118..4433384 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND678_RS21365 (4428268) 4428268..4429191 + 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -
ND678_RS21370 (4429172) 4429172..4430326 - 1155 WP_009485247.1 FAD-dependent urate hydroxylase HpxO -
ND678_RS21375 (4430672) 4430672..4432051 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
ND678_RS21380 (4432029) 4432029..4432529 + 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
ND678_RS21385 (4432526) 4432526..4432852 + 327 WP_009485245.1 hydroxyisourate hydrolase -
ND678_RS21390 (4433118) 4433118..4433384 + 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
ND678_RS21395 (4433384) 4433384..4434706 + 1323 WP_009485244.1 type II toxin-antitoxin system HipA family toxin Toxin
ND678_RS21400 (4434723) 4434723..4436015 - 1293 WP_087850048.1 glycoside hydrolase family 10 protein -
ND678_RS21405 (4436157) 4436157..4437161 - 1005 WP_009485243.1 fimbrial protein -
ND678_RS21410 (4437149) 4437149..4439650 - 2502 WP_009485242.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49157.50 Da        Isoelectric Point: 7.5062

>T248014 WP_009485244.1 NZ_CP098758:4433384-4434706 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPICEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT248014 WP_002904790.1 NZ_CP098758:4433118-4433384 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486MZ73

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References