Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 2480554..2481364 Replicon chromosome
Accession NZ_CP098758
Organism Klebsiella pneumoniae strain KP167

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag ND678_RS11925 Protein ID WP_004178461.1
Coordinates 2480831..2481364 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag ND678_RS11920 Protein ID WP_002887278.1
Coordinates 2480554..2480820 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND678_RS11900 (2476426) 2476426..2476770 - 345 WP_004214146.1 cation efflux system protein CusF -
ND678_RS11905 (2476788) 2476788..2478173 - 1386 WP_009484676.1 efflux transporter outer membrane subunit -
ND678_RS11910 (2478345) 2478345..2479028 + 684 WP_004214143.1 copper response regulator transcription factor CusR -
ND678_RS11915 (2479018) 2479018..2480451 + 1434 WP_009484674.1 Cu(+)/Ag(+) sensor histidine kinase -
ND678_RS11920 (2480554) 2480554..2480820 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
ND678_RS11925 (2480831) 2480831..2481364 + 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
ND678_RS11930 (2481412) 2481412..2482533 - 1122 WP_002887282.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T248012 WP_004178461.1 NZ_CP098758:2480831-2481364 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT248012 WP_002887278.1 NZ_CP098758:2480554-2480820 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References