Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2363231..2363747 Replicon chromosome
Accession NZ_CP098758
Organism Klebsiella pneumoniae strain KP167

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag ND678_RS11340 Protein ID WP_009486548.1
Coordinates 2363463..2363747 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag ND678_RS11335 Protein ID WP_002886901.1
Coordinates 2363231..2363473 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND678_RS11320 (2359259) 2359259..2359999 + 741 WP_009486551.1 KDGP aldolase family protein -
ND678_RS11325 (2360066) 2360066..2361220 + 1155 WP_020316350.1 lactonase family protein -
ND678_RS11330 (2361243) 2361243..2363153 + 1911 WP_009486549.1 PRD domain-containing protein -
ND678_RS11335 (2363231) 2363231..2363473 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ND678_RS11340 (2363463) 2363463..2363747 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND678_RS11345 (2363751) 2363751..2364215 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ND678_RS11350 (2364523) 2364523..2366661 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
ND678_RS11355 (2367018) 2367018..2367761 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
ND678_RS11360 (2367764) 2367764..2367937 - 174 WP_002886906.1 hypothetical protein -
ND678_RS11365 (2368067) 2368067..2368330 + 264 WP_014908078.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T248011 WP_009486548.1 NZ_CP098758:2363463-2363747 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT248011 WP_002886901.1 NZ_CP098758:2363231-2363473 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References