Detailed information of TA system TA248010

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2203642..2205323
• Replicon: chromosome
• Accession: NZ_CP098758
• Organism: Klebsiella pneumoniae strain KP167

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: ND678_RS10520
• Protein ID: WP_004146663.1
• Coordinates: 2204406..2205323 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: ND678_RS10515
• Protein ID: WP_004177809.1
• Coordinates: 2203642..2204400 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ND678_RS10500 (2199260)	2199260..2199946	-	687	WP_004151733.1	tetratricopeptide repeat protein	-
ND678_RS10505 (2200408)	2200408..2202555	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
ND678_RS10510 (2202828)	2202828..2203556	+	729	WP_002885152.1	response regulator transcription factor	-
ND678_RS10515 (2203642)	2203642..2204400	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ND678_RS10520 (2204406)	2204406..2205323	+	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ND678_RS10525 (2205448)	2205448..2206455	-	1008	WP_009484222.1	carbohydrate kinase family protein	-
ND678_RS10530 (2206530)	2206530..2207471	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
ND678_RS10535 (2207502)	2207502..2208500	-	999	WP_002885172.1	ribose ABC transporter permease	-
ND678_RS10540 (2208497)	2208497..2210017	-	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T248010 WP_004146663.1 NZ_CP098758:2204406-2205323 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT248010 WP_004177809.1 NZ_CP098758:2203642-2204400 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05