Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1886198..1886823 Replicon chromosome
Accession NZ_CP098758
Organism Klebsiella pneumoniae strain KP167

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag ND678_RS09050 Protein ID WP_002882817.1
Coordinates 1886440..1886823 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag ND678_RS09045 Protein ID WP_004150355.1
Coordinates 1886198..1886440 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND678_RS09020 (1882189) 1882189..1882788 + 600 WP_004151865.1 glucose-1-phosphatase -
ND678_RS09025 (1882782) 1882782..1883642 + 861 WP_004146232.1 virulence factor BrkB family protein -
ND678_RS09030 (1883639) 1883639..1884076 + 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
ND678_RS09035 (1884121) 1884121..1885062 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
ND678_RS09040 (1885076) 1885076..1885993 - 918 WP_009484979.1 alpha/beta hydrolase -
ND678_RS09045 (1886198) 1886198..1886440 + 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
ND678_RS09050 (1886440) 1886440..1886823 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
ND678_RS09055 (1886997) 1886997..1887926 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
ND678_RS09060 (1887923) 1887923..1888558 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
ND678_RS09065 (1888555) 1888555..1889457 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-112)

Antitoxin

(16-47)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T248009 WP_002882817.1 NZ_CP098758:1886440-1886823 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp


Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT248009 WP_004150355.1 NZ_CP098758:1886198-1886440 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References