248007

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 998853..999510 Replicon chromosome
Accession NZ_CP098758
Organism Klebsiella pneumoniae strain KP167

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag ND678_RS04710 Protein ID WP_002916310.1
Coordinates 998853..999263 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ND678_RS04715 Protein ID WP_002916312.1
Coordinates 999244..999510 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND678_RS04690 (994853) 994853..996586 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
ND678_RS04695 (996592) 996592..997305 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ND678_RS04700 (997328) 997328..998224 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ND678_RS04705 (998325) 998325..998846 + 522 WP_002916308.1 flavodoxin FldB -
ND678_RS04710 (998853) 998853..999263 - 411 WP_002916310.1 protein YgfX Toxin
ND678_RS04715 (999244) 999244..999510 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ND678_RS04720 (999756) 999756..1000739 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
ND678_RS04725 (1000890) 1000890..1001549 - 660 WP_002916317.1 hemolysin III family protein -
ND678_RS04730 (1001713) 1001713..1002024 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
ND678_RS04735 (1002074) 1002074..1002802 + 729 WP_009485882.1 MurR/RpiR family transcriptional regulator -
ND678_RS04740 (1002921) 1002921..1004354 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T248007 WP_002916310.1 NZ_CP098758:c999263-998853 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT248007 WP_002916312.1 NZ_CP098758:c999510-999244 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References