Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 5535011..5535654 Replicon chromosome
Accession NZ_CP098757
Organism Klebsiella oxytoca strain AHC-6

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NDX50_RS25885 Protein ID WP_064396313.1
Coordinates 5535011..5535427 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1V8NRE0
Locus tag NDX50_RS25890 Protein ID WP_064396317.1
Coordinates 5535424..5535654 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDX50_RS25865 (NDX50_25835) 5530700..5531368 - 669 WP_004103895.1 GTP cyclohydrolase I FolE -
NDX50_RS25870 (NDX50_25840) 5531735..5532571 + 837 WP_004103897.1 S-formylglutathione hydrolase -
NDX50_RS25875 (NDX50_25845) 5532838..5534208 + 1371 Protein_5066 IS3 family transposase -
NDX50_RS25880 (NDX50_25850) 5534388..5534882 - 495 WP_064396312.1 N-acetyltransferase -
NDX50_RS25885 (NDX50_25855) 5535011..5535427 - 417 WP_064396313.1 PIN domain-containing protein Toxin
NDX50_RS25890 (NDX50_25860) 5535424..5535654 - 231 WP_064396317.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NDX50_RS25895 (NDX50_25865) 5536376..5538349 - 1974 WP_004114107.1 catecholate siderophore receptor CirA -
NDX50_RS25900 (NDX50_25870) 5538654..5540123 - 1470 WP_004103903.1 amino acid permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 5533603..5534208 605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14938.33 Da        Isoelectric Point: 7.2449

>T248006 WP_064396313.1 NZ_CP098757:c5535427-5535011 [Klebsiella oxytoca]
VIKTYMLDTNICSFIMREQPEAVIKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGLLVEAFCARLDAILAWDRA
AVDATTEIKAALTAAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLILEDWAN

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8685.75 Da        Isoelectric Point: 4.4563

>AT248006 WP_064396317.1 NZ_CP098757:c5535654-5535424 [Klebsiella oxytoca]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFTQLEKADSDFMAERGDIVSDEGRFDL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1V8NRE0

References