Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3029098..3029717 Replicon chromosome
Accession NZ_CP098757
Organism Klebsiella oxytoca strain AHC-6

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag NDX50_RS14305 Protein ID WP_004099646.1
Coordinates 3029098..3029316 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NDX50_RS14310 Protein ID WP_004099648.1
Coordinates 3029343..3029717 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDX50_RS14270 (NDX50_14260) 3025135..3025398 + 264 WP_064396976.1 type B 50S ribosomal protein L31 -
NDX50_RS14275 (NDX50_14265) 3025398..3025538 + 141 WP_078774955.1 type B 50S ribosomal protein L36 -
NDX50_RS14280 (NDX50_14270) 3025535..3026233 - 699 WP_004099639.1 GNAT family protein -
NDX50_RS14285 (NDX50_14275) 3026335..3027789 + 1455 WP_224313875.1 PLP-dependent aminotransferase family protein -
NDX50_RS14290 (NDX50_14280) 3027764..3028234 - 471 WP_004111038.1 YlaC family protein -
NDX50_RS14295 (NDX50_14285) 3028265..3028402 + 138 WP_224226357.1 hypothetical protein -
NDX50_RS14300 (NDX50_14290) 3028371..3028937 - 567 WP_023320460.1 maltose O-acetyltransferase -
NDX50_RS14305 (NDX50_14295) 3029098..3029316 - 219 WP_004099646.1 HHA domain-containing protein Toxin
NDX50_RS14310 (NDX50_14300) 3029343..3029717 - 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
NDX50_RS14315 (NDX50_14305) 3030199..3033345 - 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit AcrB -
NDX50_RS14320 (NDX50_14310) 3033368..3034561 - 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T248001 WP_004099646.1 NZ_CP098757:c3029316-3029098 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT248001 WP_004099648.1 NZ_CP098757:c3029717-3029343 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References